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NFkB: A POTENTIAL PLAYER IN HUMAN MESENCHYMAL STEM CELL PLURIPOTENCY

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Abstract:

Human adult mesenchymal stem cells (hMSCs) are pluripotent and are crucial in the mediation of the human inflammatory response. MSCs are primarily found in the adult bone marrow (BM), are of mesodermal origin and can differentiate into lineage specific cells of the connective tissue, fat, stroma, cartilage, and bone. hMSCs are capable of preserving, producing and restoring terminally differentiated cells of their lineage as a result of physiologic cell turnover or tissue damage due to injury. This characteristic enhanced the current appreciation of the vast therapeutic potential of hMSCs. Thus far, MSCs have demonstrated therapeutic use in diseases such as: coronary artery disease, spinal cord injury, Parkinson’s disease and liver regeneration. Scientists must however, fully understand the underlying mechanism by which these cells sustain their pluripotency. Although few genes, such as Oct4, Nanog and Sox2 have been linked to pluripotency, it is imperative to identify the master regulatory gene of pluripotency in these cells. More specifically, researchers must fully understand how to manipulate the microenvironment surrounding the site of injury to maintain the curative potential of these cells in vivo. NFkappaB is a family of transcription factors found abundantly in sites of injury and known to be important regulators of inflammatory responses. Various stimuli such as cytokines, stress and pathogens have been shown to elicit NFkappaB regulated immune responses or more specifically, the activation of various genes involved in the inflammatory response. The NFkappaB family shares Rel homology and is inhibited by inhibitory kappa B (IkB) proteins. Inflammatory mediators such as NFkappaB and others at regions of tissue injury affect the development of human MSCs. It is hypothesized that NFkappaB maintains pluripotency in MSCs by directly and indirectly regulating the expression of Oct4, Nanog and Sox-2 and may ultimately be the master regulator of pluripotency in these cells.
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Association:
Name: Connecticut's Stem Cell Research International Symposium
URL:
http://stemconn.org


Citation:
URL: http://citation.allacademic.com/meta/p365949_index.html
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MLA Citation:

King, Cecile. and Greco, Steve. "NFkB: A POTENTIAL PLAYER IN HUMAN MESENCHYMAL STEM CELL PLURIPOTENCY" Paper presented at the annual meeting of the Connecticut's Stem Cell Research International Symposium, Omni Hotel, New Haven, CT, Mar 23, 2009 <Not Available>. 2014-11-29 <http://citation.allacademic.com/meta/p365949_index.html>

APA Citation:

King, C. C. and Greco, S. , 2009-03-23 "NFkB: A POTENTIAL PLAYER IN HUMAN MESENCHYMAL STEM CELL PLURIPOTENCY" Paper presented at the annual meeting of the Connecticut's Stem Cell Research International Symposium, Omni Hotel, New Haven, CT <Not Available>. 2014-11-29 from http://citation.allacademic.com/meta/p365949_index.html

Publication Type: Poster
Review Method: Peer Reviewed
Abstract: Human adult mesenchymal stem cells (hMSCs) are pluripotent and are crucial in the mediation of the human inflammatory response. MSCs are primarily found in the adult bone marrow (BM), are of mesodermal origin and can differentiate into lineage specific cells of the connective tissue, fat, stroma, cartilage, and bone. hMSCs are capable of preserving, producing and restoring terminally differentiated cells of their lineage as a result of physiologic cell turnover or tissue damage due to injury. This characteristic enhanced the current appreciation of the vast therapeutic potential of hMSCs. Thus far, MSCs have demonstrated therapeutic use in diseases such as: coronary artery disease, spinal cord injury, Parkinson’s disease and liver regeneration. Scientists must however, fully understand the underlying mechanism by which these cells sustain their pluripotency. Although few genes, such as Oct4, Nanog and Sox2 have been linked to pluripotency, it is imperative to identify the master regulatory gene of pluripotency in these cells. More specifically, researchers must fully understand how to manipulate the microenvironment surrounding the site of injury to maintain the curative potential of these cells in vivo. NFkappaB is a family of transcription factors found abundantly in sites of injury and known to be important regulators of inflammatory responses. Various stimuli such as cytokines, stress and pathogens have been shown to elicit NFkappaB regulated immune responses or more specifically, the activation of various genes involved in the inflammatory response. The NFkappaB family shares Rel homology and is inhibited by inhibitory kappa B (IkB) proteins. Inflammatory mediators such as NFkappaB and others at regions of tissue injury affect the development of human MSCs. It is hypothesized that NFkappaB maintains pluripotency in MSCs by directly and indirectly regulating the expression of Oct4, Nanog and Sox-2 and may ultimately be the master regulator of pluripotency in these cells.


Similar Titles:
Reprogrammimg of human fibroblasts derived from osteogenesis imperfecta (OI) patients into induced pluripotent stem (iPS) cells

Characterization of WAT and BAT Adipogenesis from Unique Human Mesenchymal Stem Cell Sources

Cortical neuronal protection in spinal cord injury (SCI) following transplantation of BDNF-human mesenchymal stem cells (hMSCs)

Generation of Muscle Progenitor Cells from Human Pluripotent Stem Cells


 
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